Analysis Of Urinary Symptoms And Urodynamic Findings In Multiple Sclerosis Patients By Gender And Disease Subtype

Article Information

Article Type: Research Article

Citation: Cox L, Cameron AP, Wittman D, Papin JE, Mao-Draayer Y, et al. (2015) Analysis of Urinary Symptoms and Urodynamic Findings in Multiple Sclerosis Patients by Gender and Disease Subtype. J Neurol Neurobiol 1 (2): http://dx.doi.org/10.16966/2379-7150.105

Copyright:© 2015 Cox L, et al. This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history:

 Received date: 22 April, 2015

 Accepted date: 29 April, 2015

 Published date: 05 May, 2015


Authors :

Cox L,      Cameron AP,      Wittman D,      Papin JE,      Mao-Draayer Y,      He C,      Clemens JQ,      Wei JT,      Sarma AV,      Stoffel JT*

Department of Urology, University of Michigan, 1500 E. Medical Center Dr. SPC 5330 Ann Arbor, MI, USA

*Corresponding author: John Stoffel, MD, University of Michigan,Department of Urology 1500 E. Medical Center Dr. SPC 5330 Ann Arbor, MI, USA, Tel: 48109-5330; E-mail: jstoffel@med.umich.edu

Abstract

Background: Although urinary symptoms are prevalent in multiple sclerosis (MS), there is little information whether bladder function differs by gender or disease subtype.

Objective: Differences in MS bladder function within subgroups were investigated by comparing female to male and relapsing remitting (RRMS) to secondary progressive (SPMS) patients.

Methods: We reviewed 118 MS patients referred for urologic evaluation between 2007 and 2012 and extracted demographic, questionnaire (AUASI, M-ISI), and urodynamic data. Variables were analyzed by gender and MS subtype, and a multivariable regression model was generated to adjust for age and gender

Results: The cohort consisted of83/35 female/male and 57/61RRMS/SPMS subjects. Urinary questionnaire and urodynamic findings were similar between genders, with the exception of higher maximum voiding pressures in males (p=0.003). RRMS patients reported more bothersome urinary symptoms compared to SPMS (AUASI21 vs. 15, p=0.004) and RRMS was independently associated with higher symptom scores on multivariable analysis (OR 17.1, p=0.008). There were no differences in urodynamic findings between subtypes.

Conclusions: Male and female MS patients had similar urinary symptom scores and urodynamic findings, with the exception of higher voiding pressures in males. RRMS patients reported significantly more severe urinary symptoms on AUASI, compared to SPMS, despite having similar urodynamic findings

Keywords
Multiple sclerosis; Neurogenic bladder; Urodynamic testing; Gender

Table 1: Characteristics by of Multiple Sclerosis Cohort Grouped by Disease Subtype


Table 2: Characteristics by of Multiple Sclerosis Cohort Grouped by Gender


Table 3:Characteristics by of Multiple Sclerosis Cohort Grouped by Disease Subtype


Table 4:Multivariable Analysis for Association between MS Subtype and Urinary Symptoms and Voiding PressuresAdjusted for Age and Gender

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