Somatomotor and Behavioral Changes Following Traumatic Brain Injury

Article Information

Article Type: Research Article

Citation: Citation: Adams S, Condrey JA, Wen Tsai H, Svetlov SI, Prima V, Davenport PW (2015) Somatomotor and Behavioral Changes Following Traumatic Brain Injury. Neurol Neurobiol, Volume1.1: http://dx.doi.org/10.16966/2379-7150.104

Copyright: © 2015 Adams S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history:

 Received date: 26 February, 2015.

 Accepted date: 12 March, 2015.

 Published date: 17 March, 2015.

Authors :

 Sherry Adams ¹       Jillian A. Condrey ¹       Hsiu-Wen Tsai ¹       Stanislav I. Svetlov ²       Victor Prima ²       Paul W. Davenport ^1*    
1Department of Physiological Sciences, University of Florida, Gainesville FL, USA
²2Department of Medicine and Psychiatry, 1600 SW Archer Road, Box 100274, University of Florida, Gainesville, FL, USA

*Corresponding author: Dr. Paul W. Davenport, Department of Physiological Sciences, University of Florida, Gainesville, FL 32603, USA, Tel: 352-294-4025; Fax: 352-392-5145; E-mail: pdavenpo@ufl.edu

Abstract

Overpressurization blast (OB) exposure used to induce traumatic brain injury (TBI) in the rodent model can result in somatomotor and behavioral changes. Increased anxiety is evidenced after OB TBI in Dorsal and Frontal blast-wave exposed injured animals. Sustained impaired somatosensory functions occur after multiple OB injuries in Dorsal animals. Somatomotor function is impaired acutely but partially recovers after OB injury in Frontal animals. The Dorsal Group had reduction in risk-taking behavior in Group 1 (low pressure OB) and in total exploration in Group 2 (high pressure OB). The critical time point for somatosensory and somatomotor function impairment occurs at 24 hours post-OB injury with Group 1 demonstrating somatosensory and Group 2 demonstrating somatomotor deficits. The results suggest orientation and pressure magnitude have a significant impact on behavioral outcome measures following OB injuries as well as cumulative effects of repeated OB.



Table 1: Somatomotor evaluation after OB injury in sprague-dawley rats

Table 2: EPM evaluation after OB injury in sprague-dawley rats

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. *Denotes statistically significant change of values within group. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.

Table 3: EPM evaluation after dorsal OB injury in sprague-dawley rats

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. *Denotes statistically significant change of values within group. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.

Table 4: Somatomotor tests for sham, dorsal and frontal groups

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.

Table 5: Somatomotor tests for dorsal groups 1 and 2

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. *Denotes statistically significant change from time value within group. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.

Table 6: Somatosensory tests for sham, dorsal and frontal groups

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. *Denotes statistically significant change of values within group. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.

Table 7: Somatosensory tests for dorsal groups 1 and 2

Data expressed as mean ± SD. One-way ANOVA test followed by post hoc analysis by Tukey HSD method. *Denotes statistically significant change from time value within group. Intergroup comparison one-way ANOVA test followed by post hoc analysis by Tukey HSD method.


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