Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson’s Disease

Article Information

Aritcle Type: Short Communication

Citation: Tekin I, Vgontzas A, Lewis MM, Kothari S, Kong L, et al. (2015) Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson’s Disease. J Neurol Neurobiol 1(1): doi http://dx.doi. org/10.16966/2379-7150.109

Copyright: © 2015 Tekin I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history:

 Received date: 3 July 2015

 Accepted date: 20 July 2015

 Published date: 25 July 2015

Authors :

Izel Tekin¹   Angeliki Vgontzas²   Mechelle M Lewis^1,3   Saira Kothari³    Lan Kong⁶   Yue Lu⁸   Kent E Vrana¹   Xuemei Huang<sup>1,3,4,5,7*

1</sup>Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA²Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA³Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA⁴Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA, USA⁵Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, USA⁶Department of Public Health Sciences Pennsylvania State University College of Medicine, Hershey, PA, USA⁷Department of Kinesiology, Pennsylvania State University, University Park, PA, USA⁸Department of Kinesiology, Statistics8 Pennsylvania State University, University Park, PA, USA*Corresponding author: Xuemei Huang, MD, PhD, Departments of Neurology, Penn State University-Hershey Medical Center, H037 500 University Drive, Hershey, PA 17033-0850, USA Tel: 717-531-0003-287082; E-mail: Xuemei@psu.edu


Abstract

Background

Parkinson’s disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear.

Objective

To explore whether peripheral injury and associated chronic limb pain may influence the side of onset.

Methods

We administered a questionnaire to 128 PD patients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained.

Results

Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030).

Conclusions

Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.

Keywords

Parkinson’s disease; Peripheral limb injury; Side of onset; Handedness

Figure 1: Distribution of subjects with a history of peripheral injury and PD side of onset. The numbers on top of the columns indicate the number of subjects in each group. The upper panel describes all PD subjects separated by right side injury, left side injury, and no history of injury. The bottom panel shows the distribution of subjects according to their chronic injury side and whether they have suffered chronic pain due to injury.

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